Prof. Dr. Tom Ganten

Fellow-Klasse 2011-12
Fellow-Klasse 2012-13

Forschungsgebiete:

Forschung zum HCC, Fokussierung auf die TNF-related Apoptosis-inducing Ligand-induzierte Apoptose in Tumorzellen und normalen Gewebe; Forschung zur Bedeutung von Immunsupressiva auf die Entwicklung von Hepatitis C, HCC und Diabetes

Curriculum Vitae
 

Arbeitsvorhaben

Ausgewählte Publiaktionen:

• S Brost, R Koschny, J Sykora, W Stremmel, F Lasitschka, H Walczak, Ganten TM. Differential expression of the TRAIL/TRAIL-receptor system in patients with inammatory bowel disease, Pathol Research and Pract 2010 Jan 15; 206 (1): 43-50.
• Ganten TM, Sykora J, Koschny R, Batke E, Aulmann S, Mansmann U, Stremmel W, Sinn HP, Walczak H. Prognostic signicance of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor expression in patients with breast cancer. J Mol Med. 2009 Oct; 87(10): 995-1007.
• Holland H, Koschny R, Krupp W, Meixensberger J, Bauer M, Schober R, Kirsten H, Ganten TM, Ahnert P. Cytogenetic and molecular biological characterization of an adult medulloblastoma. Cancer Genet Cytogenet. 2007 Oct 15; 178(2): 104-113.
• Ganten TM, Edmundo Aravena, Jaromir Sykora, Ronald Koschny, Jutta Mohr, Jochen Rudi, Wolfgang Stremmel, Henning Walczak. Helicobacter pylori-induced apoptosis in T cells is mediated by mitochondrial apoptosis and serves as a model of immune evasion. Eur J Clin Invest. 2007 Feb; 37(2): 117-125.
• Koschny R, Ganten TM, Sykora J, Haas TL, Sprick RM, Kolb A,Walcak H. TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specic apoptosis within a therapeutic window. Hepatology. 2007 Mar; 45(3): 649-658.
• Ganten TM, Koschny R, Sykora J, Schulze-Bergkamen H, Büchler P, Haas TL, Schader MB, Untergasser A, Stremmel W, Walczak H. Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs. Clinical Cancer Research (2006), Clin Cancer Res 12(8): 2640-2646.
• Ganten TM, Ronald Koschny, Tobias L. Haas, Jaromir Sykora, Min Li Weber, Kerstin Herzer, Peter Krammer and Henning Walczak Proteasome inhibition sensitises hepatocellular carcinoma cells but not primary human hepatocytes for TRAIL-induced apoptosis. Hepatology. (2005) 42: 588-597.
• Ganten TM, Haas TL, Stahl H, Sprick MR, Weigand MA, Grosse-Wilde A, Stremmel W, Krammer PH,Walczak H. Enhanced DISC formation is responsible for sensitisation to TRAILinduced apoptosis by chemotherapeutic drugs. Cell Death and Differentiation (2004), Jul; 11Suppl 1: S. 86-96.
• Koschny R, Schmidt J, Ganten TM. Beyond Milan criteria-chances and risks of expanding transplantation criteria for HCC patients with liver cirrhosis. Clin Transplant. 2009 Dec; 23 Suppl 21:49-60.
• Ganten MK, Weber MA, Ganten TM. Cellular mechanisms of tumor response: Clinical demands. Radiologe. 2008 Sep; 48(9): 820-831. German.