Dyregulation of Protein Translation – Final retreat

Dysregulation of translation is a characteristic of many, if not all, human cancers and is linked to aberrant proliferation, survival, angiogenesis, immune response, and tumor metabolism. However, despite its medical importance, the molecular basis of the relationship between dysregulated translation and cancer remains elusive. Recent methodological advances including genome-wide profiling of translating ribosomes, allow for the first time the identification of specific translation-associated pathways and factors that are dysregulated in cancer. Our consortium has a strong background in the analysis of various mechanisms that control protein translation in normal cells, including the identification of a control system in translation re-initiation, the role of silent mutations in translational regulation and protein folding, the discovery of novel elements regulating a class of mRNAs, and the function of RNA modifications in translational fidelity. Using primary colorectal tumor sphere cultures as a central model, we follow a synergistic approach to investigate the role of functional defects of translation in tumor formation.

Contact person:
Deutsches Krebsforschungszentrum
Universität Heidelberg
Prof. Dr. Aurelio Teleman
Im Neuenheimer Feld 580
69120 Heidelberg
Telefon: 06221 421620
E-Mail: a.teleman@dkfz.de

Contact person:
Deutsches Krebsforschungszentrum
Universität Heidelberg
Dr. Sabine Rehberger-Schneider
Im Neuenheimer Feld 580
69120 Heidelberg
Telefon: 06221 421628
E-Mail: sabine.rehberger-schneider@dkfz-heidelberg.de