Contact

2020

• Hybrid multimodal imaging synthons for chemoselective and efficient biomolecule modification with chelator and near-infrared fluorescent cyanine dye. R. Huebner, V. v.Kiedrowski, V. Benkert, B. Waengler, R. Schirrmacher, R. Krämer, C. Waengler, Pharmaceuticals, 2020, 13(9), 250.
   
• Probing two PESIN-indocyanine-dye-conjugates: significance of the used fluorophore. R. Huebner, V. Benkert, X. Cheng, B. Waengler, R. Krämer, C. Waengler, Journal of Materials Chemistry B: Materials for Biology and Medicine, 2020, 8(6), 1302-1309.

2019

• Phenomenological investigation of the cytotoxic activity of fucoidan isolated from Fucus vesiculosus. A. Zayed, T. Hahn, D. Finkelmeier, A. Burger-Kentischer, A. Rupp, R. Krämer, R. Ulber, Process Biochemistry (Oxford, United Kingdom), 2019, 81, 182-187.

2018

• An immobilized perylene diimide derivative for fucoidan purification from a crude brown algae extract. A. Zayed, C. Dienemann, C. Giese, R. Krämer, R. Ulber, Process Biochemistry (Oxford, United Kingdom), 2018, 65, 233-238.

2017

• Polyamine-modified near-infrared cyanine dyes for targeting the nuclei and nucleoli of cells.
  S.G. König, R. Krämer, Dyes Pigments, 2017, 145, 80-94.
  
  
   
• Accessing Structurally Diverse Near-Infrared Cyanine Dyes For Folate Receptor-Targeted Cancer Cell Staining.
  S. König, R. Krämer, Chem. Eur. J., 2017, 23, 1-8.
  
  
   
• A Fluorescent Probe for Glycosaminoglycans Applied to the Detection of Dermatan Sulfate by a Mix-and-Read Assay.
  M. Rappold, U. Warttinger, R. Krämer, Molecules, 2017, 22, 768.
  
  

2016

 

• A Chromogenic and Fluorogenic Peptide Substrate for the Highly Sensitive Detection of Proteases in Biological Matrices
  D. Arian, J. Harenberg, R. Kraemer, Journal of Medicinal Chemistry 2016, 59(16), 7576-7583.
  
  ​​
  
  ​​​
• A fluorescent probe assay (Heparin Red) for direct detection of heparins in human plasma
  U. Warttinger, C. Giese, J. Harenberg, E. Holmer, R. Kraemer, Analytical and Bioanalytical Chemistry 2016, 408(28), 8241-8251.
  
  ​
  
   
• Coronene-​Containing N-​Heteroarenes: 13 Rings in a Row
  A. Endres, M. Schaffroth, F. Paulus, H. Reiss, H. Wadepohl, F. Rominger, R. Kraemer, U. H. F. Bunz, Journal of the American Chemical Society 2016, 138(6), 1792-1795.
  
  ​
  
  ​
   
• Measurement of dabigatran, rivaroxaban and apixaban in samples of plasma, serum and urine, under real life conditions. An international study
  J. Harenberg, S. Du, M. Wehling, S. Zolfaghari, C. Weiss, R. Kraemer, J. Walenga, Clinical Chemistry and Laboratory Medicine 2016, 54(2), 275-283.
   
• Zinc(II)​-​induced control of the internalization of a near-​infrared fluorescent probe by live cells
  S. Koenig, S. Oez, R. Kraemer, Molecular BioSystems 2016, 12(4), 1114-1117.
  
  ​​
  ​Reproduced from Ref. above with permission from the Royal Society of Chemistry

2015

• A polyamine-​modified near-​infrared fluorescent probe for selective staining of live cancer cells
  S. Koenig, S. Oez, R. Kraemer, Chemical Communications (Cambridge, United Kingdom) 2015, 51(34), 7360-7363.
  
  ​
  Reproduced from Ref. above with permission from the Royal Society of Chemistry
  ​​
• Determination of dabigatran in plasma, serum, and urine samples: comparison of six methods
  S. Du, C. Weiss, C. Giese, S. Kraemer, M. Wehling, R. Kraemer, J. Harenberg, Clinical Chemistry and Laboratory Medicine 2015, 53(8), 1237-1247.
   
• Fluorescent perylene derivatives for direct detection of heparin
  R. Kraemer, H. Szelke, J. Harenberg, A. Poeck, U.S. 2015, US 9006261 B2 20150414.
   
• Measurement of Non-​Vitamin K Antagonist Oral Anticoagulants in Patient Plasma Using Heptest-​STAT Coagulation Method
  S. Du, J. Harenberg, S. Kraemer, R. Kraemer, M. Wehling, C. Weiss, Therapeutic Drug Monitoring 2015, 37(3), 375-380.
   
• Patients' Serum and Urine as Easily Accessible Samples for the Measurement of Non-​Vitamin K Antagonist Oral Anticoagulants
  J. Harenberg, S. Du, S. Kraemer, C. Weiss, R. Kraemer, M. Wehling, Seminars in Thrombosis and Hemostasis 2015, 41(2), 228-236.

2014

• Determination of direct oral anticoagulants from human serum samples
  J. Harenberg, S. Kraemer, S. Du, C. Giese, A. Schulze, R. Kraemer, C. Weiss, Seminars in Thrombosis and Hemostasis 2014, 40(1), 129-134.
   
• Measurement of rivaroxaban and apixaban in serum samples of patients
  J. Harenberg, S. Kraemer, S. Du, S. Zolfaghari, A. Schulze, R. Kraemer, C. Weiss, M. Wehling, G. Y. H.  Lip, European Journal of Clinical Investigation 2014, 44(8), 743-752.

2013

• Monitoring Cu2+-​Binding to a DNA-​Clip-​phen Conjugate and Metal-​centered Redox Processes by a Fluorescent Reporter Group
  A. Sproedefeld, A. Kiel, D.-P. Herten, R. Kraemer, Zeitschrift fuer Anorganische und Allgemeine Chemie 2013, 639(8-9), 1636-1639.
   
• Novel methods for assessing oral direct factor Xa and thrombin inhibitors: use of point-​of-​care testing and urine samples
  J. Harenberg, S. Du, S. Kraemer, C. Giese, A. Schulze, C. Weiss, R. Kraemer, Seminars in Thrombosis and Hemostasis 2013, 39(1), 66-71.
   
• Concept of a point of care test to detect new oral anticoagulants in urine samples
  J. Harenberg, S. Kraemer, S. Du, C. Weiss, R. Kraemer, Thrombosis Journal 2013, 11:15.

2012

• Analysis of direct factor Xa inhibitors
  J. Harenberg, R. Kraemer, PCT Int. Appl. 2012, WO 2012069139 A1 20120531.
   
• Determination of dabigatran in human plasma samples
  J. Harenberg, C. Giese, S. Marx, R. Kraemer, Seminars in Thrombosis and Hemostasis 2012, 38(1), 16-22.
   
• Determination of direct thrombin inhibitors in fluids like serum or urine
  J. Harenberg, R. Kraemer, PCT Int. Appl. 2012, WO 2012175183 A1 20121227.
   
• Determination of rivaroxaban in human plasma samples
  J. Harenberg, S. Erdle, S. Marx, R. Kraemer, Seminars in Thrombosis and Hemostasis 2012, 38(2), 178-184.
   
• Determination of the anticoagulant effects of new oral anticoagulants: an unmet need.
  J. Harenberg, S. Marx, S. Erdle, R. Krämer. Expert Review of Hematology 2012, 5(1), 107-113.
   
• Metal complex derivatives of peptide nucleic acids (PNA)
  R. Krämer, A. Mokhir, Metal Ions in Life Sciences 2012, 10(Interplay between Metal Ions and Nucleic Acids), 319-340.
  
  ​
  
  ​​

2011

• Determination of an international sensitivity index of thromboplastin reagents using a WHO thromboplastin as calibrator for plasma spiked with rivaroxaban.
  J. Harenberg, S. Marx, R. Krämer, Ch. Giese, Ch. Weiss. Blood Coagulation & Fibrinolysis 2011, 22(8), 637-641.
   
• Determination of rivaroxaban by different factor Xa specific chromogenic substrate assays: reduction of interassay variability.
  J. Harenberg, R. Krämer, Ch. Giese, S. Marx, Ch. Weiss, M. Wehling. Journal of Thrombosis and Thrombolysis 2011, 32(3), 267-271.
   
• Far-field nanoscopy with reversible chemical reactions.
  M. Schwering, A. Kiel, A. Kurz, K. Lymperopoulos, A. Sprödefeld, R. Krämer, D.-P. Herten, Angewandte Chemie, Int. Ed. 2011, 50(13), 2940-2945.
  
  ​
  
  
   
• Fluorescent perylene derivatives for direct detection of heparin.
  R. Krämer, H. Szelke, J. Harenberg, A. Poeck. PCT Int. Appl. 2011, WO 2011020887 A1 20110224.

2010

• New reaction of 1H-pyrazoles with selenium dioxide: one-pot synthesis of bis(1H-pyrazol-4-yl)selenides.
  M. Sereduyk, I. Fritsky, R. Krämer, H. Kozlowski, M. Haukka, P. Guetlich. Tetrahedron 2010, 66(45), 8772-8777.
  
  ​
  
  ​​
   
• Combinatorial oligo FISH: directed labeling of specific genome domains in differentially fixed cell material and live cells.
  E. Schmitt, J. Schwarz-Finsterle, S. Stein, C. Boxler, P. Müller, A. Mokhir, R. Krämer, Ch. Cremer, M. Hausmann. Methods in Molecular Biology 2010, 659, 185-202
  
  ​
  
  ​
   
• Pattern-based sensing of sulfated glycosaminoglycans with a dynamic mixture of iron complexes.
  P.-K. Müller-Graff, H. Szelke, K. Severin, R. Krämer. Org. Biol. Chem. 2010, 8(10), 2327-2331.
  
  ​
  
  ​​
   
• A fluorescent probe for the quantification of heparin in clinical samples with minimal matrix interference.
  H. Szelke, S. Schuebel, J. Harenberg, R. Krämer. Chem. Commun. 2010, 46(10), 1667-1669.
  
  ​
  
  ​​
  Reproduced from Ref. above with permission from the Royal Society of Chemistry
   
• A fluorescent redox sensor with tuneable oxidation potential.
  R. M. Kierat, B. M. B. Thaler, R. Krämer. Bioorg. Med. Chem. Lett. 2010, 20(4), 1457-1459.
  
  ​
  
  ​​
   
• Interaction of heparin with cationic molecular probes: Probe charge is a major determinant of binding stoichiometry and affinity.
  H. Szelke, S. Schuebel, J. Harenberg, R. Krämer. Bioorg. Med. Chem. Lett. 2010, 20(4), 1445-1447.
  
  ​
  
  ​​

2009

• Detection and neutralisation of heparin by a fluorescent ruthenium compound
  H. Szelke, J. Harenberg, R. Krämer, Thromb. Haemost. 2009, 102(5), 859-864.
   
• On a way to new types of the polyfunctional and polytopic systems based on cage metal complexes: Cadmium-promoted nucleophilic substitution with low-active nucleophilic agents
  O. Varzatskii, Y. Voloshin, S. Korobko, S. Shulga, R. Krämer, A. Belov, A. Vologzhanina, Y. Bubnov, Polyhedron 2009, 28(16), 3431-3438.
   
• Lanthanide-based fluorogenic peptide substrate for the highly sensitive detection of thermolysin
  A.-K. Marguerre, R. Krämer, Bioorg. Med. Chem. Lett. 2009, 19(19), 5757-5759.
  
  ​
  
  ​​
• Toward an allosteric metalated container
  H. Szelke, H. Wadepohl, M. Abu-Youssef, R. Krämer, Eur. J. Inorg. Chem. 2009, (2), 251-260.

2008

• Quantification of hydrogen peroxide by triggered reconstitution of horseradish peroxidase using a modified hemin
  R. Krämer, V. Pavlov. PCT Int. Appl. 2008, EP 1990347 A1 20081112.
   
• Using enzymatic amplification by aldolase for the optical detection of DNA by an artificial signal cascade
  N. Graf, S. Kassube, R. Krämer, Bioorganic & Medicinal Chemistry Letters 2008, 18(17), 4786-4788.
  
  ​
  
  ​​
• Probing single-stranded DNA and its biomolecular interactions through direct catalytic activation of factor XII, a protease of the blood coagulation cascade
  V. Pavlov, M. Zorn., R. Krämer, Collection Symposium Series 2008 (10), 268-271.
   
• Near infrared fluorophore for the selective labeling of membranes in cells
  Z. Kaya, R. Krämer. PCT Int. Appl. 2008, WO 2008037394 A2 20080403.

2007

• Bis(3,5-dimethyl-1H-pyrazolyl) selenide - a new bidentate bent connector for preparation of 1D and 2D co-ordination polymers
  M. Seredyuk, M. Haukka, I. O. Fritsky, H. Kozlowski, R. Krämer, V. A. Pavlenko, P. Guetlich, Dalton Trans. 2007, (29), 3183-3194
   
• First hybrid oximehydrazonate phthalocyaninoclathrochelates: The synthesis and properties of lutetium phthalocyanine-capped cage iron(II) complexes
  Y. Z. Voloshin, O. A. Varzatskii, L. G. Tomilova, M. O. Breusova, T. V. Magdesieva, Y. N. Bubnov, R. Krämer, Polyhedron 2007, 26(12), 2733-2740.
  
  ​
  
  ​​
• Direct monitoring of formation and dissociation of individual metal complexes by single-molecule fluorescence spectroscopy
  A. Kiel, J. Kovacs, A. Mokhir, R. Krämer, D.-P. Herten, Angew. Chem. Intern. Ed. 2007, 46(18), 3363-3366.
  
  ​
  
  ​​
• Synthesis of new phenanthroline-based heteroditopic ligands - highly efficient and selective fluorescence sensors for copper(II) ions
  P. Comba, R. Krämer, A. Mokhir, K. Naing, E. Schatz, Eur. J. Inorg. Chem. 2007, 4442-4448.
   
• Single-molecule studies on individual metal complexes
  A. Kiel, A. Jaerve, J. Kovacs, A. Mokhir, R. Krämer, D. Herten, Proceedings of SPIE, 2007, 6444.

2006

• Probing single-stranded DNA and its biomolecular interactions through direct catalytic activation of factor XII, a protease of the blood coagulation cascade
  V. Pavlov, M. Zorn, R. Krämer, Biochem. Biophys. Res. Commun. 2006, 349, 1011-1015.
   
• Enzymatic amplification in a bioinspired, autonomous signal cascade
  N. Graf, R. Krämer, Chem. Commun. 2006, 4375-4376.
  
  ​
  Reproduced from Ref. above with permission from the Royal Society of Chemistry
  ​​
• Metal complex catalysis on a double stranded DNA template
  I. Boll, E. Jentzsch, R. Krämer, A. Mokhir, Chem. Commun. 2006, 3447-3449.
  
  ​
  Reproduced from Ref. above with permission from the Royal Society of Chemistry
  ​​
• A selective fluorescent sensor for Cu2+ and its immobilization on CPG beads
  L. Kovbasyuk, R. Krämer. Inorgan. Chem. Commun., 2006, 9, 586-590.

• Zn2+ dependent DNA binders based on terminally modified peptide nucleic acids
  I. Boll, L. Kovbasyuk, R. Krämer, T. Oeser, A. Mokhir. Bioorg. Med. Chem. Lett., 2006, 16, 2781-2785

• Cellular Uptake of PNA−Terpyridine Conjugates and Its Enhancement by Zn2+ Ions
  A. Fuessl, A. Schleifenbaum, M. Goeritz, A. Riddell, C. Schultz, R. Krämer, Roland. J. Am. Chem. Soc., 2006, 128, 5986-5987.
  
  ​
  
  ​
• A Metal-Ion-Releasing Probe for DNA Detection by Catalytic Signal Amplification
  N. Graf, M. Göritz, R. Krämer, Angew. Chem. Int. Ed., 2006, 45, 4013-4015.
  
  ​
  
  ​​
• Supramolecular bioinorganic hybrid catalysts for enantioselective transformations (Highlight)
  R. Krämer, Angew. Chem. Int. Ed., 2006, 45, 858-860.

2005

• Allosteric Control of Oligonucleotide Hybridization by Metal-Induced Cyclization
  M. Göritz, R. Krämer, J. Am. Chem. Soc., 2005, 127, 18016-18017.
  
  ​
  
  ​​
• A fluorogenic and chromogenic probe that detects the esterase activity of trace copper(II)
  R. Kierat, R. Krämer, Bioorg. Med. Chem. Lett., 2005, 15, 4824-4827.
  
  ​
  ​
  
   
• Fluorescent Sensor for Cu2+ with a Tunable Emission Wavelength
  A. Mokhir, A. Kiel, D.-P. Herten, R. Krämer, Inorg. Chem., 2005, 44, 5661-5666.
  
  ​
  
  ​​
• N,N:N′,N′-Bis(2,2'-dihydroxybiphenyl-3,3'-dimethylidene)benzene-1,2-diamine dimethyl sulfoxide tetrasolvate
  P. Plitt, F. Rominger, R. Krämer, Acta Cryst. C, 2005, C61, 396-397.
   
• Double discrimination by binding and reactivity in fluorescent metal ion detection
  A. Mokhir, R. Krämer, Chem. Commun. 2005, 2244-2246.
  
  ​
  Reproduced from Ref. above with permission from the Royal Society of Chemistry
  ​
• Templated Metal Catalysis for Single Nucleotide Specific DNA Sequence Detection
  I. Boll, R. Krämer, J. Brunner, A. Mokhir, J. Am. Chem. Soc., 2005, 127, 7849-7856.
  
  ​
  
  ​​
• Biphenyl derived oxovanadium(IV) and copper(II) salen-type complexes – structure and redox tuning
  P. Plitt, H. Pritzkow, T. Oeser, R. Kraemer, J. Inorg. Biochem. 2005, 99, 1230-1237.
   
• Coordination Chemistry of the Ditopic Ligand 4-[6-(2-Pyridyl)-2-pyridyl]-6-(2-pyridyl)pyrimidine: Encapsulation of Nitrate by [2 × 2]Grid Complexes
  L. Kovbasyuk, H. Pritzkow, R. Krämer, Eur. J. Inorg. Chem., 2005, 894-900.
   
• Hybridization dependent cleavage of internally modified disulfide–peptide nucleic acids
  I. Boll, R. Krämer, A. Mokhir, Bioorg. Med. Chem. Lett., 2005, 15, 505-509.
   
• Mono-, Di- and Polymeric Calcium and Gadolinium Complexes of the Tripodal Ligand 2,2′,2′′-Nitrilotribenzoic Acid
  S. Wörl, H. Pritzkow, I. O. Fritsky, R. Krämer, Eur. J. Inorg. Chem., 2005, 759-765.
   
• Synthesis of a novel dinucleating aminocarboxylate macrocycle and structures of its dinuclear complexes with di- and trivalent transition and lanthanide metal ions
  J. Brunner, H. Pritzkow, R. Krämer, Dalton Trans., 2005, 338-343.
   
• Synthesis, structure and magnetism of a new ferromagnetic hexanuclear nickel cluster with a dicubane-like core
  S. Wörl, H. Pritzkow, I. O. Fritsky, R. Krämer, Dalton Trans., 2005, 27-29.
  
  ​
  
  ​
• Density functional theory analysis of dimethylphosphate hydrolysis: effect of solvation and nucleophile variation
  P. Imhof, S. Fischer, R. Krämer, J. Smith, J. Mol. Struct. Theochem, 2005, 713, 1-5.

2004

• Copper(II)-Quenched Oligonucleotide Probes for Fluorescent DNA Sensing
  J. Brunner, R. Krämer, J. Am. Chem. Soc., 2004, 126, 13626-13627.
  
  ​
  
  ​​
• On, off and intermediate coordination of a bridgehead triarylamine donor in tripodal complexes: Towards the tuning of coordinative bond distance
  S . Wörl, D. Hellwinkel, H. Pritzkow, M. Hofmann, R. Krämer, Dalton Trans. 2004, 2750-2757.
  
  ​
  
  ​
• Biphenyl derived Schiff-base vanadium(V) complexes with pendant OH-groups—structure, characterization and hydrogen peroxide mediated sulfide oxygenation
  P. Plitt, H. Pritzkow, R. Krämer, Dalton Trans. 2004, 2314-2320.
   
• ​Allosteric Supramolecular Receptors and Catalysts
  L. Kovbasyuk, R. Krämer, Chem. Rev., 2004, 104, 3161-3187.
   
• Zn2+-Dependent Peptide Nucleic Acids Probes
  A. Mokhir, R. Krämer, H. Wolf, J. Am. Chem. Soc., 2004, 126, 6208-6209.
  
  ​
  
  ​​
• Synthesis and DNA binding properties of dioxime–peptide nucleic acids
  A. Mokhir, R. Krämer, Y. Z. Voloshin, O. A. Varzatskii. Bioorganic & Medicinal Chemistry Letters, 2004, 14, 2927-2930.
   
• DNA-templated catalysis using a metal-cleavable linker
  F. H. Zelder, J. Brunner, R. Krämer. Chem. Commun., 2004, 902-903.
  
  ​
  Reproduced from Ref. above with permission from the Royal Society of Chemistry
  ​
• On/off regulation of catalysis by allosteric control of metal complex nuclearity
  L. Kovbasyuk, H. Pritzkow, R. Krämer, I. O. Fritsky. Chem. Commun., 2004, 880-881.
  
  ​
  Reproduced from Ref. above with permission from the Royal Society of Chemistry
  ​
• Self-assembly of a molecular figure-of-eight strip
  S. Woerl, D. Hellwinkel, H. Pritzkow, R. Krämer, Chem. Commun., 2004, 28-29.
  
  ​
  Reproduced from Ref. above with permission from the Royal Society of Chemistry
  ​
• Organotin(IV) complexes of polyhydroxyalkyl carboxylic acids and some related ligands
  A. Szorcsik, L. Nagy, B. Gyurcsik, G. Vanko, R. Kraemer, A. Vertes, T. Yamaguchi, K. Yoshida, J. Radioanal. Nucl. Chem. 2004, 260, 459-469.