Retreat - Translation Regulation- Stoecklin - Teleman Labs

Dysregulation of translation is a characteristic of many, if not all, human cancers and is linked to aberrant proliferation, survival, angiogenesis, immune response, and tumor metabolism. However, despite its medical importance, the molecular basis of the relationship between dysregulated translation and cancer remains elusive. Recent methodological advances including genome-wide profiling of translating ribosomes, allow for the first time the identification of specific translation-associated pathways and factors that are dysregulated
in cancer. Our consortium has a strong background in the analysis of various mechanisms that control protein translation in normal cells, including the identification of a control system in translation re-initiation, the role of silent mutations in translational regulation and protein folding, the discovery of novel elements regulating a class of mRNAs, and the function of RNA modifications in translational fidelity. Using primary colorectal tumor sphere cultures as a central model, we follow a synergistic approach to investigate the role of functional
defects of translation in tumor formation.

Veranstalter

Prof. Dr. Dr. Georg Stoecklin 
Medizinische Fakultät Mannheim
der Universität Heidelberg
Ludolf-Krehl-Str. 13-17
68167 Mannheim

Prof. Dr. Aurelio Teleman 
Krebs- und stoffwechselassoziierte Signaltransduktion (B140)
DKFZ TP3
Im Neuenheimer Feld 580
69120 Heidelberg

Ansprechpartner
Dr. Sabine Rehberger-Schneider
Email: Sabine.Rehberger-Schneider@dkfz-heidelberg.de