Development of immune modulatory RNAs

Cartoon of how immune modulatory RNAs are working — © Georg Stoecklin, MI3, UMM

The expression of numerous cytokines is controlled by different RNA-binding proteins (RNA-BPs), which regulate the stability and translation of cytokine mRNAs. In “Synthetic Immunology” project 4, we design and optimize immune-modulatory RNAs (imodRNAs) with the aim to sequester specific RNA-BPs. Upon packaging and delivery, imodRNAs are expected to alter cytokine expression and thereby modulate immune responses.

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Table

Georg Stoecklin	Principal Investigator
Kerstin Göpfrich	Principal Investigator
Andres Jeschke	Principal Investigator
Janina Lehmann	Postdoc
Hsu-Min Sung	Postdoc
Chih-Yuan Kao	PhD student
Joachim Spatz	Principal Investigator
Nina Papavasiliou	Principal Investigator
Michael Platten	Principal Investigator
Adelheid Cerwenka	Principal Investigator

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