Core Facility Metabolomics Core Technology Platform

The Metabolomics Core Technology Platform (MCTP) is a DFG-registered (RI492) core facility of the Heidelberg University and is part of the Centre for Organismal Studies (COS).

The MCTP determines concentrations of small molecules in biological samples on a recharge, non-profit base. Depending on the requirements of your project, we offer tailor-made solutions as well as standardized Metabolomics assays.

We strive to provide high-quality analytical services at competitive prices, and regularly customize and develop assays to fit our users’ needs. We are project partner of the bio-medical research consortium SMART-CARE as well as the CRC 1118 “reactive metabolites as a cause of diabetic complications”.

In addition, we are one of the few certified laboratories worldwide for Metabolomics kit based assays developed by Biocrates.

decorative image: a collage of 4 photos shows some of the matrices that the facility offers to analyze. In the center a transparent red square overlaps the photos with white text: Analyzed Matrices - Prokaryotes; yeast; cell cultures; tissue, e.g. human, animal, plant; body fluids, e.g. blood, urine, CSF; supernatants, e.g. from cultures; further matrices can be established upon request

Project Request

All researchers of the University of Heidelberg, the Heidelberg and Mannheim University Hospital, DKFZ, MPImF and EMBL are welcome to request help or place orders for metabolite analyses. External projects can be accepted upon discussion.

Illustrated MCTP Timeline with 6 steps for Service Requests: 1. First Contact via Email to metabolomics-projects@uni-heidelberg.de, 2. Research Plan: Setting Project aims, 3. Online Request via iLab (see Button “Ordering&Billing” on Website), 4. Sample Submission: Samples are submitted according to guidelines, 5. Lab Work: Measurements are performed / Methods are developed, 6. Analysis results: results are sent out.

Before sample submission please:

follow the steps of our sample submission checklist.
read carefully the general guideline for metabolite analyses with specified requirements for metabolite analyses.
see our end-user license agreement (EULA) for more general information on the MCTP's services as well as users' rights and duties. New customers are requested to bring a signed copy of the EULA when submitting the first sample set.

The costs of core facility services – system usage and consumables - have to be charged directly to the users. For detailed prices of the different analyses please contact the MCTP. Prices can also be seen upon login to the online booking system.

The MCTP uses an online system from iLab Solutions designed to streamline the process of ordering and billing for core service requests.

Ordering & Billing Services & Equipment

Team

Table

Scientific Director

Prof. Dr. Rüdiger Hell

Scientific Staff

Dr. Michael Büttner

Postdoc

Dr. Glynis Klinke

Technical Assistant

Dipl.-Ing. Eva-Maria Käshammer-Lorenz

Technical Assistant

Dipl.-Geoökol. Nina Kunze-Rohrbach

Technical Assistant

Dipl.-Biol. Michael Schulz

Administration

Birgit Maresch

Contact

For project related enquiries:
metabolomics-projects@uni-heidelberg.de

For sample submission and pickup:
metabolomics-samples@uni-heidelberg.de

Managing Director
Dr. Gernot Poschet

gernot.poschet@cos.uni-heidelberg.de

Scientific Director
Prof. Dr. Rüdiger Hell

ruediger.hell@cos.uni-heidelberg.de

Shipping Address
MCTP
Centre for Organismal Studies
Universität Heidelberg
Im Neuenheimer Feld 360
69120 Heidelberg
Germany

Map Screenshot of the MCTP´s location in Heidelberg´s Botanical Garden

Publications

Selection of recent publications with significant contribution of MCTP members

Table

Erben V, Poschet G, Schrotz-King P, Brenner H. (2021) Comparing Metabolomics Profiles in Various Types of Liquid Biopsies among Screening Participants with and without Advanced Colorectal Neoplasms. Diagnostics 11(3):561.
Mock-Ohnesorge J, Mock A, Hackert T, Fröhling S, Schenz J, Poschet G, Jäger D, Büchler MW, Uhle F, Weigand MA. (2021) Perioperative changes in the plasma metabolome of patients receiving general anesthesia for pancreatic cancer surgery. Oncotarget. 12(10):996-1010.
Friedrich M, Sankowski R, Bunse L, Kilian M, Green E, Guevara C, Pusch S, Poschet G, Sanghvi K, Hahn M, Bunse T, Münch P, Gegner H, Sonner J, von Landenberg A, Cichon F, Aslan K, Trobisch T, Schirmer L, Abu-Sammour D, Kessler T, Ratliff M, Schrimpf D, Sahm F, Hopf C, Heiland D, Schnell O, Beck J, Böttcher C, Fernandez-Zapata C, Priller J, Heiland S, Gutcher I, Quintana F, von Deimling A, Wick W, Prinz M, Platten M (2021) Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas. Nat Cancer 2, 723–740.
Sadik A, Somarribas Patterson LF, Öztürk S, Mohapatra SR, Panitz V, Secker PF, Pfänder P, Loth S, Salem H, Prentzell MT, Berdel B, Iskar M, Faessler E, Reuter F, Kirst I, Kalter V, Foerster KI, Jäger E, Guevara CR, Sobeh M, Hielscher T, Poschet G, Reinhardt A, Hassel JC, Zapatka M, Hahn U, von Deimling A, Hopf C, Schlichting R, Escher BI, Burhenne J, Haefeli WE, Ishaque N, Böhme A, Schäuble S, Thedieck K, Trump S, Seiffert M, Opitz CA. (2020) IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression. Cell 182(5):1252-1270.
Jaskulski S, Jung AY, Huebner M, Poschet G, Hell R, Hüsing A, Gonzalez-Maldonado S, Behrens S, Obi N, Becher H, Chang-Claude J. (2020) Prognostic associations of circulating phytoestrogens and biomarker changes in long-term survivors of postmenopausal breast cancer. Nutr Cancer 72(7):1155-1169.
Schenz J, Tamulyte S, Nusshag C, Brenner T, Poschet G, Weigand MA, Uhle F. (2020) Population-Specific Metabolic Alterations in Professional Antigen-Presenting Cells Contribute to Sepsis-Associated Immunosuppression. Shock. 53(1):5-15.
Nietzel, T., Mostertz, J., Ruberti, C., Née, G., Fuchs, P., Wagner, S., Moseler, A., Müller-Schüssele, S.J., Benamar, A., Poschet, G., Büttner, M., Møller, I.M., Lillig, C.H., Macherel, D., Wirtz, M., Hell, R., Finkemeier, I., Meyer, A.J., Hochgräfe, F. & Schwarzländer, M. (2020) Redox-mediated kick-start of mitochondrial energy metabolism drives resource-efficient seed germination. Proceedings National Academy Science U.S.A. 117: 741-751.

Funding Resources

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