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Zhang, X. M., Herrmann, U., Weyer, S. W., Both, M., Müller, U. C., Korte, M., and Draguhn, A. (2013). Hippocampal network oscillations in APP/APLP2-deficient mice. PLoS ONE, in press

 

Shariati, S. A. M., Lau, P., Hassan, B. A., Müller, U.C., Dotti, C. G., Strooper, B.,  and Annette Gärtner, A. (2013) APLP2 regulates neuronal stem cell differentiation during cortical development J. Cell Sci, in press.

 

Kaufmann, M. R., Barth, S., Konietzko, U., Wu, B., Egger, S., Kunze, R., Marti, H. H., Hick, M., Müller, U., Camenisch, G., and Wenger, R. H.  (2013) Dysregulation of Hypoxia-Inducible Factor by Presenilin/g-Secretase Loss-of-Function Mutations. J Neurosci 33: 1915–1926.

 

Marcus O. W. Grimm, M. O.W., Zinser, E. G., Grösgen, S., Hundsdörfer, B., Rothhaar, T. L., Burg, V. K., Kaestner, L., Bayer, T. A., Lipp, P., Müller, U., Grimm, H. S., and Hartmann, T. (2012). Amyloid Precursor Protein (APP) Mediated Regulation of Ganglioside Homeostasis Linking Alzheimer’s Disease Pathology with Ganglioside Metabolism. PLoS ONE, 7 , e34095

 

Peter Jedlicka, P.,Owen, M., Vnencak, M.,  Jakob-A. Tschape, J.-A., Hick, M, Müller, U. C.  and Deller, T.  (2011) Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivo. Exp Brain Res, DOI 10.1007/s00221-011-2911-9

 

Weyer SA, Klevanski M, Delekate A, Voikar V, Aydin D, Hick M, Filippov MA, Drost N, Schaller KL, Saar M, Vogt MA, Gass P, Samanta A, Jäschke A, Korte M, Wolfer DP, Caldwell JH, Müller UC. (2011) APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP . EMBO J, 30:2266-80.doi:10.1038/emboj.2011.119
 

Aydin D, Filippov MA, Tschäpe J-A, Gretz N, Prinz M, Eils R, Brors B, Müller UC. 2011. Comparative transcriptome profiling of Amyloid Precursor Protein family members in the adult cortex. BMC Genomics,  12:160.
 

Grimm, M.O.W., Grösgen, S., Rothhaar, T. L., Burg,  V. K., Hundsörfer,  B., Haupenthal, V. J., Friess,  P., Müller UC, Fassbender, K., Riemenschneider, M., Grimm, H. S., and Hartmann, T. (2011) Intracellular APP domain (AICD) regulates serine-palmitoyl-CoA transferase (SPT) expression and is affected in Alzheimers disease. J. Neurochem 116:916-25.
 

Grimm, M.O.W., Kuchenbecker, J., Rothhaar, T. L., Grösgen, S., Hundsdörfer, B., Burg, V. K., Friess, P., Müller UC., Grimm, H. S., Riemenschneider, M., and Tobias Hartmann, T.  (2010).  Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase (AGPS) by amyloid precursor protein (APP) processing and is affected in Alzheimer’s disease, J. Neurochem 116:916-25.
 

Anliker, B., Abel,T., Kneissl,S., Hlavaty, J., Caputi, A., Brynza, J., Schneider, I. C.,  Muench, R. C., Petznek, H., Kontermann, R. E., Koehl, U., Johnston, I. C. D., Keinänen, K., Müller UC. C., Hohenadl, C., Monyer, H., Cichutek, K., and Buchholz, C. J. (2010). Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors. Nature Methods 7:929-35.
 

Manzke, T., Niebert, M., Koch, U. W., Caley, A., Vogelgesang, S.,Hülsmann,S., Ponimaskin, E., Müller UC., Smart,T. S., Harvey,  R. J., and Richter, D. W. (2010). The Glycine Receptor α3 is a Molecular Switch Controlling Mammalian Breathing Rhythm. J. Clin Invest 20:4118-4128.
 

Copanaki, E., Chang, S., Vlachos, A., Tschäpe, J.-A., Müller UC. C., Kögel, D., Deller, T. (2010). sAPPα antagonizes dendritic degeneration and neuron death triggered by  proteasomal stress. Mol Cell Neurosci 44:386-393
 

Bergmans, B. A., Shariati, S. A. M., Habets, R. L.P., Verstreeken, P., Schoonjans, L., Müller UC., Dotti, C., DeStrooper, B. (2010). Neurons generated from APP/APLP1/APLP2 triple knockout neurons behave normally in vitro and in vivo: lack of evidence for a cell autonomous role of AP in neuronal differentiation. Stem cells 28:399-406.
 

Mallm, J.-P., Jakob-Andreas Tschäpe, J. A., Hick, M., Filippov, M. A. and C. Müller UC. (2010). Generation of conditional null alleles for APP and APLP2. Genesis 48: 200
 

Frank S, Copanaki E, Burbach G, Müller UC, Deller T (2009) Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice. Neurosci Lett 453: 41-4
 

Szodorai A, KuanY-H, Hunzelmann S, Engel U, Sakane A, Sasaki T, Takai Y, Kirsch J, Müller UC, Beyreuther K, Brady S, Morfini G, Kins S (2009) APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle. J Neurosci 29: 14534-44.
 

Bach, P., Tschäpe, J.-A., Kopietz, F., Braun, G., Baade, J. K., Wiederhold, K.-H., Staufenbiel, M., Prinz|, M., Deller , T., Kalinke, U., J. Buchholz, C. J. and Müller UC. C. (2009). Vaccination with Aβ-displaying virus-like particles reduces soluble and insoluble cerebral A and lowers plaque burden in APP transgenic mice. J. Immunology 182: 7613
 

Frank. S., Copanaki, E., Burbach, G. J., Ulrike C. Müller UC. C., and Deller, T. Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice  (2009), Neuroscience Letters,  453:41-44.
 

Lourenço, F. C.,  Galvan,V.,  Fombonne,  J., Corset, V., Llambi, F., Müller UC., , Bredesen, D. E., and Mehlen, P., Netrin-1 interacts with amyloid precursor protein and regulates amyloid-b production (2009). Cell Death and Diff, 16:655-63.
 

Tamboli, I.,  Prager, K.,  Thal, D. R.,  Thelen, K. M., Dewachter4, I., Pietrzik, C.  U.,  St. George-Hyslop, P., Sisodia, S. S., Filippov, M.,  Müller UC., van Leuven, F.,  Lütjohann, D., and Walter, J. Loss of g-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis (2008). J. Neuroscience, 28:1207-12106.
 

Gakhar-Koppole, N., Hundeshagen, P., Mandl, C., Alliquant, B., Müller UC., and Ciccolini, F. Neuronal activity promotes secretion of Amyloid Precursor Protein  (sAPP) leading to neurite outgrowth in neural stem cells derived neurons via  activation of MAPK pathway (2008). Eur J Neurosci, 28:871–882.
 

Schrenk-Siemens, K. , Perez-Alcala, S. , Richter, J. , Lacroix, E., Rahuel, J., Korte3, M., Müller UC., Barde, Y.-A.  and Bibel, M.  (2008) Embryonic Stem Cell-derived Neurons as a Cellular System to Study Gene Function: Lack of Amyloid Precursor Proteins APP and APLP2 Leads to Defective Synaptic Transmission. Stem Cells, 26:2153-2163.
 

Ring. S, Weyer, S., Kilian, S. B., Waldron, E., Pietrzik, C. U., Filippov, M., Herms, J., Buchholz, C., Eckman, C. B., Martin Korte, M., Wolfer, D. P. and Müller UC. (2007) The secreted APPsα domain is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP deficient mice  J. Neuroscience, 27:7817-7826.
 

Back S, Haas P, Tschape JA, Gruebl T, Kirsch J, Müller UC, Beyreuther K, and Kins S. (2007) Beta-amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment.  J Neurosci Res, 85:2580-2590.
 

Hirzel*, K., Müller UC. , Latal*, A. T., Hülsmann, S., Grudzinska, J., Seeliger, M. W., Heinrich Betz, H. and Laube, B. (2006). Hyperekplexia phenotype of glycine receptor 1 subunit mutant mice identifies Zn2+ as an essential endogenous modulator of glycinergic neurotransmission. * authors contributed equally Neuron 52:679.
 

Anliker, B. and Müller UC. (2006). The functions of the mammalian amyloid precursor protein and related amyloid precursor-like proteins.  Neurodegenerative Diseases 3:239-246.
 

Hebert, S.S., Serneels, L. , Tolia, A., Craessaerts, K., Derks,C., Filippov, M. A., Müller UC., DeStrooper, B. (2006). Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes. EMBO reports 7:739-45. 
 

Siemes, C., Quast, T., Kummer, C., Wehner, S., Kirfel, G., Müller UC. and Herzog, V. (2006) Keratinocytes from APP/APLP2 deficient mice are impaired in proliferation, adhesion and migration in vitro. Exp Cell Res. 312: 1939-49.

 

Selected publications 2005 and earlier:

Grimm, M. O. W., Grimm, H. S., Pätzold, A. J., Zinser, E. G., Halonen, R., Duering, M., Tschäpe, J.-A., De Strooper, B., Müller UC., Shen, J. and Hartmann, T. (2005). Regulation of cholesterol and sphingomyelin metabolism by amyloid- and presenilin. Nat. Cell. Biol. ,7: 1118-1123.
 

Soba, P. , Eggert, S., Zentgraf, H., Siehl, K., Kreger, S., Löwer,A., Langer, A., Merdes, G., Paro, R.,. Masters, C. L., Müller UC., Kins, S. and Konrad Beyreuther. (2005) Homo- and hetero-dimerization of APP family members promotes intercellular adhesion. EMBO J., 24: 3624-3634
 

Herms, J., Anliker, B., Heber, S., Ring. S., Fuhrmann, M., Kretzschmar, H., Sisodia, S. and Müller UC. (2004). Cortical Dysplasia Resembling Human Type 2 Lissencephaly in Mice Lacking all Three APP-Family Members. The EMBO J. 23: 4106 - 4115
 

Caille, I., Alliquant, B., Dupont, E., Bouillot, C., Langer, A., Müller UC. and Pronchiantz, A. (2004). Soluble form of Amyloid precursor protein regulates proliferation of Progenitors in the adult subventricular zone. Development, 131: 2173.
 

Harvey, R., Depner, U.,Wässle,H., Ahmadi, S., Heindl, C., Reinold, H., Smart, T., Harvey, K., Schütz, B., Akbari, O., Zimmer, A., Poisbeau, P., Welzl, H.,Wolfer, D. P., Betz, H., Zeilhofer, U., and Müller UC. (2004). GlyR3: an essential target for spinal PGE2-mediated inflammatory pain sensitization. Science 304: 884.
 

Müller UC., Cristina, N., Li, Z.W., Wolfer, D. P., Lipp, H.-P., Rülicke, T., Brandner, S., Aguzzi, A. & Weissmann, C. (1994). Behavioral and Anatomical Deficits in Mice homozygous for a Modified -Amyloid Precursor Gene. * authors contributed equally. Cell 79: 755-765.