Publications - TP7
Kögel D, Concannon CG, Müller T, König H, Bonner C, Poeschel S, Chang S, Egensperger R, Prehn JH (2011).The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis. Neurobiol Aging. 2011 Jul 29. [Epub ahead of print]
Eckert GP*, Chang S*, Eckmann J, Copanaki E, Hagl S, Hener U, Müller WE, Kögel D (2011). Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing. BBA Biomembranes. 1808: 236-243.
Gamerdinger M, Kaya AM, Wolfrum U, Clement AM, Behl C (2011) BAG3 mediates chaperone-based aggresome-targeting and selected autophagy of misfolded proteins. EMBO Rep 12(2):149-56.
Copanaki E, Chang S, Vlachos A, Tschäpe JA, Müller UC, Kögel D*, Deller T* (2010). sAPPalpha antagonizes dendritic degeneration and neuron death triggered by proteasomal stress. Mol Cell Neurosci. 44: 386-393.
Klinkenberg M, Thurow N, Gispert S, Ricciardi F, Eich F, Prehn JH, Auburger G, Kögel D (2010). Enhanced vulnerability of PARK6 patient skin fibroblasts to apoptosis induced by proteasomal stress. Neuroscience. 166: 422-434.
Mocko JB, Kern A, Moosmann B, Behl C, Hajieva P (2010) Phenothiazines interfere with dopaminergic neurodegeneration in Caenorhabditis elegans models of Parkinson's disease. Neurobiol Dis 40(1):120-9.
Voss V, Senft C, Lang V, Ronellenfitsch MR, Steinbach JP, Seifert V, Kögel D (2010). The Pan-Bcl-2 inhibitor (-)-gossypol triggers autophagic cell death in malignant glioma. Mol Cancer Res, 8: 1002-1016.
Weissenberger J, Priester M, Bernreuther C, Rakel S, Glatzel M, Seifert V, Kögel, D (2010). Dietary Curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1, 2/STAT3 signaling pathway. Clin Cancer Res, 16: 5781-5795.
Clement AB, Gamerdinger M, Tamboli IY, Lütjohann D, Walter J, Greeve I, Gimpl G, Behl C (2009) Adaptation of neuronal cells to chronic oxidative stress is associated with altered lipid homeostasis and lysosomal function. J Neurochem 111:669-82.
Gamerdinger M, Hajieva P, Kaya AM, Wolfrum U, Hartl FU, Behl C (2009) Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3. EMBO J 28:889-901.
Hajieva P, Mocko JB, Moosmann B, Behl C (2009a) Novel imine antioxidants at low nanomolar concentrations protect dopaminergic cells from oxidative neurotoxicity. J Neurochem 110:118-132.
Hajieva P, Kuhlmann C, Luhmann HJ, Behl C (2009b) Impaired calcium homeostasis in aged hippocampal neurons. Neurosci Lett 451:119-123.
Hanstein R, Trotter J, Behl C, Clement AB (2009) Increased connexin 43 expression as a potential mediator of the neuroprotective activity of the corticotropin-releasing hormone. Mol Endocrinol 23:1479-1493.
Peters I, Igbavboa U, Schütt T, Haidari S, Hartig U, Rosello X, Böttner S, Copanaki E, Deller T, Kögel D, Wood WG, Müller WE, Eckert GP (2009). The interaction of beta-amyloid protein with cellular membranes stimulates its own production. BBA Biomembranes. 1788: 964-972.
Witan H, Gorlovoy P, Kaya AM, Koziollek-Drechsler I, Neumann H, Behl C, Clement AM (2009) Wild-type Cu/Zn superoxide dismutase (SOD1) does not facilitate, but impedes the formation of protein aggregates of amyotrophic lateral sclerosis causing mutant SOD1. Neurobiol Disease 36:331-42.
Clement AB, Hanstein R, Schroder A, Nagel H, Endres K, Fahrenholz F, Behl C (2008) Effects ofneuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress. Neuroscience 152:459-468.
Hetschko H, Voss V, Senft C, Seifert V, Prehn JH, Kögel D (2008). BH3 mimetics reactivate autophagic cell death in anoxia-resistant malignant glioma cells. Neoplasia. 10: 873-885.
Hanstein R, Lu A, Wurst W, Holsboer F, Deussing JM, Clement AB, Behl C (2008) Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress. Neuroscience 156:712-721.
Rami A, Kögel D (2008). Apoptosis meets autophagy-like cell death in the ischemic penumbra: Two sides of the same coin? Autophagy 4: 422-426.
Witan H, Kern A, Koziollek-Drechsler I, Wade R, Behl C, Clement AM (2008) Heterodimer formation of wild-type and amyotrophic lateral sclerosis-causing mutant Cu/Zn-superoxide dismutase induces toxicity independent of protein aggregation. Hum Mol Genet 17(10):1373- 1385.
Concannon CG, Koehler BF, Reimertz C, Murphy BM, Bonner C, Thurow N, Ward MW, Villunger A, Strasser A, Kögel D*, Prehn JHM* (2007). Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway. Oncogene, 26: 1681-1692.
Müller T, Concannon CG, Ward MW, Kögel D, Prehn JHM, Egensperger R (2007). Modulation of gene expression and cytoskeletal dynamics by the APP intracellular domain (AICD). Mol Biol Cell, 18: 201-210.
Copanaki E, Schürmann T, Eckert A, Leuner K, Müller WE, Prehn JHM, Kögel D (2007). The Amyloid Precursor Protein potentiates CHOP induction and cell death in response to ER Ca2+ depletion. BBA Mol Cell Res, 1773: 157-165.
Gamerdinger M, Manthey D, Behl C (2006) Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells--implications for neuroprotection against Ca-mediated excitotoxicity. J Neurochem 97:57-68.
Gerlach R, Demel G, König H-G, Groß U, Prehn JHM, Raabe A, Seifert V, Kögel D (2006). Active secretion of S100B from astrocytes during metabolic stress. Neuroscience, 141: 1697-1701.
Hajieva P and Behl C (2006) Antioxidants as a potential therapy against age-related neurodegenerative diseases: Amyloid beta toxicity and Alzheimer’s disease. Curr Pharm Des 12:699-704.
Kern A, Roempp B, Prager K, Walter J, Behl C (2006) Down-regulation of endogenous amyloid precursor protein processing due to cellular aging. J Biol Chem 281:2405-2413.
Kögel D, Svensson B, Copanaki E, Anguissola S, Bonner C, Thurow N, Gudorf D, Hetschko H, Müller T, Peters M, König H-G, Prehn JHM (2006). Induction of Transcription Factor CHOP Mediates Hypoglycemia-Induced Necrotic Cell Death in Human Neuroblastoma Cells. J Neurochem, 99: 952-964.
Schultz C, König H-G, Del Turco D, Politi C, Eckert GP, Ghebremedhin E, Prehn JHM, Kögel D, Deller T (2006). Coincident enrichment of phosphorylated IκBα, activated IKK, and phosphorylated p65 in the axon initial segment of neurons. Mol Cell Neurosci, 33: 68-80.
Selected publications 2005 and earlier:
Marsicano G, Goodenough S, Monory K, Hermann H, Eder M, Cannich A, Azad SC, Cascio MG, Gutierrez SO, van der Stelt M, Lopez-Rodriguez ML, Casanova E, Schutz G, Zieglgansberger W, Di Marzo V, Behl C, Lutz B (2003) CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science 302:84-88.
