Development of immune modulatory RNAs
![Cartoon of how immune modulatory RNAs are working](/sites/default/files/styles/img_free_aspect_0005/public/2022-06/image%20imodRNAs%2016x9%20v2.jpg?itok=NF2v-SzI)
The expression of numerous cytokines is controlled by different RNA-binding proteins (RNA-BPs), which regulate the stability and translation of cytokine mRNAs. In “Synthetic Immunology” project 4, we design and optimize immune-modulatory RNAs (imodRNAs) with the aim to sequester specific RNA-BPs. Upon packaging and delivery, imodRNAs are expected to alter cytokine expression and thereby modulate immune responses.
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